5+ Best Prokinetics for SIBO Management

The best prokinetics for SIBO management are substances that aim to help gastrointestinal mobility move more efficiently. With poor posture, lack of exercise, and declining gut health, managing SIBO becomes a more complex challenge to tackle for people all over the world. Elders require extensive support through supplements such as prokinetic medications to minimize potential motility issues.
At Nudge, we aim to improve your gut health by providing an all-in-one health supplement that targets the three root causes of SIBO. Small Intestinal Bacterial Overgrowth (SIBO) signifies several complications ranging from lack of appetite to intense abdominal pain. We ensure that our solution not only aids in mitigating the issues of improper gut health but also improves the core nutrition of each person through proper clinical practice.
Our extensive research into understanding small intestinal bacterial overgrowth tackles the usage of prokinetic drugs to target the pain points of SIBO. We will discuss the connection of this type of medication with SIBO management while also breaking down the best prokinetics for SIBO, depending on your body type and age.
Let's begin!
What are Prokinetics?

Prokinetics are medications that enhance gastrointestinal motility, aiding in the movement of food through the digestive tract. Stimulating contractions around the muscles of the gastrointestinal tract aids in alleviating underlying symptoms of GERD (gastrointestinal reflux disease), gastroparesis, and constipation.
Enhancing food movement through the digestive tract enables prokinetics to reduce the proliferation of bacteria in the small intestine. This helps alleviate symptoms associated with SIBO, such as chronic constipation and gut bacteria buildup. Other prokinetics aid by blocking certain neurotransmitters to help your body focus on healthy gut motility and migrating motor complex.
Connection to SIBO Management
When choosing the best prokinetics for SIBO management, it's important to consider factors such as efficacy, safety, and individual health status. Prokinetics help improve gastrointestinal motility, which is often impaired in individuals with SIBO. Although each supplement targets gut healing, the materials and core target differ depending on age, gender, and health status.
Consult with a gastrointestinal medical representative to inquire about the complications that can arise with prolonged exposure to prokinetics. Dietary restrictions and habitual changes are also integral to fully capitalizing on the effects of these supplements for long-term reliability and targeting the underlying cause of SIBO.
5 Best Prokinetics for SIBO Management
The best prokinetics for SIBO management can be found in natural and synthetic variants. Each supplement is designed to tackle the wide range of issues brought about by prolonged intestinal bacteria formation. Drug-based prokinetic agents, as opposed to natural alternatives, require prior acknowledgment and recommendation when treating GI motility disorders:

Here is our systematic review of the 5+ best prokinetics for SIBO management:
1. 5-HTP - Serotonin-Based Prokinetic
5-HTP utilizes serotonin as its base for treating gut issues, making it one of the best prokinetics for SIBO. Serotonin directly impacts the enteric nerves, which can help users who suffer from severe constipation due to a lack of serotonin in their system. However, balancing 5-HTP is essential, as overusing this supplement can lead to an inverse increase in diarrhea risks.
Patients who are currently taking medications for anxiety, depression, or other illnesses should consult with their doctors before taking 5-HTP. Caution is essential to balancing out medications with SSRIs needed when using such a medication, as imbalances in the system could potentially cancel out the medicine entirely.
5-HTP is found in conjunction with other prokinetic supplements by infusing the medication with natural ingredients to further boost intestinal motility. Here are some brands that incorporate 5-HTP as their main prokinetic effect structure:
- MotilPro: This prokinetic brand utilizes a combination of 5-HTP, vitamin B, ginger root, amino acid, and acetyl L-carnitine. It is designed to be taken after meals with 1 to 2 capsules a day.
- Prokine: Prokine is a nutraceutical blend using B vitamins, prokinetic herbs, bitter herbs, and a serotonin precursor as its combination base. This potent substance should be taken once after a meal instead of before due to its various roots, such as gentian root, peppermint extract, and cinnamon.
2. Triphala - Antibacterial Antioxidant
Triphala is one of the best prokinetics for SIBO while minimizing the need to take pills or supplements for results. This Indian herb is famous for being an excellent antibacterial antioxidant for overall long-term gut improvement. The lack of notable side effects makes this choice a must for SIBO patients with sensitive stomachs, and even suitable for younger and older individuals.
Herbal supplements are available for people who don't have access to the seeds directly, with expected results consistently showcasing 86% at increased gastric emptying in tests. Triphala powder can also be used as both a gastrointestinal booster as well as a mouthwash to help treat bacteria that could otherwise be swallowed into one's gut.
Prokinetics utilizing this natural substance are typically mixed with various dried fruit plants to help counteract the strong impact of Triphala herbs. One prime example is ayur-triphala, a prokinetic that combines three types of plants: Emblica officinalis, Terminalia chebula, and Terminalia bellirica to fight slow motility and improve the human immune system.
3. Magnesium Glycinate - High Bodily Enzymes
Magnesium glycinate is a natural prokinetic that targets multiple body parts, including those with poor motility. One of the main benefits of using prokinetics that takes advantage of magnesium as its base ingredient is its extensive background research in improving individuals' physical and mental health.
Its high bodily enzymes and amino acids make this substance a great substitute as a calming property. Better sleep quality, as well as relieving anxiety, are a common occurrence with the treatment of patients ingesting magnesium glycinate. Patients can also reduce inflammation within their guts through prolonged usage.
Prokinetics with magnesium has a high absorption rate for stomach acid while supporting muscle relief and better nervous system health. A popular brand of magnesium-based prokinetics is Metagenics Mag Glycinate, which uses magnesium glycinate as its primary cofactor in treating severe metabolic processes, making it one of the best prokinetics for SIBO.
4. Artichoke Leaf - IBS Suppressant

Artichoke leaves are a natural alternative to prolonging gut motility due to their next-level intervention for clients with stubborn constipation. This bitter substance contains cynaropicrin, which helps ease digestion or control stomach acidity. Artichoke leaves can be taken as medication or directly as a bitter tea to help with SIBO treatment.
Herbal blends containing artichoke leaves are best taken 15 to 20 minutes before a meal to fully encapsulate their digestive-boosting properties. Patients with gallbladder issues who are currently pregnant or nursing should avoid high intake of artichoke leaves, as it can significantly affect common allergens within the body.
Most prokinetic supplements combine this substance with other natural blends, such as ginger root extracts, to delay gastric emptying. Some brands that focus on improving both gut motility as well as liver health include the following:
- Motility Pro: This prokinetic is primarily a blend of artichoke leaves and ginger root to stimulate the upper GI tract. Take the medication for 2 capsules at night to help make the gut symptoms of SIBO dormant for the following day.
- Motility Activator: This medication is similar to Motility Pro, which uses artichoke leaves and ginger root extracts as its base. However, it should not be used by patients with ragweed allergies or gallbladder complications.
5. Licorice Root - Aids in Faster Motility

Patients constantly suffering from bloating due to slow digestion can use licorice roots to help speed up motility within their system. This powerful demulcent herb and adrenal ally aid in stopping constipation brought about by a lack of digestive chemicals. Licorice roots are also easily integrated with some of the best natural prokinetics for SIBO to create a more potent combination.
SIBO management requires careful deliberation with healthcare professionals to ensure that the healing properties of this root coincide with bodily chemical production. This is suitable with IBS patients suffering from high blood sugar. Ulcer treatment and prevention, alongside potential colon cancer and leukemia treatment, commonly use licorice root as a base substance to help deal with apoptosis (cell death).
Licorice root, aside from being among the best prokinetics for SIBO, is a commonly mixed ingredient in natural supplements that relieve digestion issues and are reliable adrenal aids. Check out these popular prokinetic supplements that use licorice roots as their main foundation:
- Megaguard: Contains digestive aiding properties of ginger root and artichoke leaves with the soothing relief of licorice root, making this a great option for patients needing help dealing with nausea caused by gastritis or food poisoning.
- Gutgard: This prokinetic contains a patented mixture of various nutrients, with licorice root extracts as its main base. Clinical testing showcases effective stomach acid-balancing properties and promotes better gut motility.
6. Ginger Root - Provides Varied Digestive Aid Benefits
One of the most flexible natural substances found to help with digestion issues is ginger root. The special constituents found in its root activate and suppress multiple receptors within the gut. It helps stabilize stomach acid production while also promoting healthy motility.
Researchers use ginger root as a common base for natural supplements and prokinetics. They combine it with other common root extracts to create a solid all-around medication for treating gastrointestinal disorders. Ginger roots are also accessible, making them an affordable option for ginger tea, especially those looking for immediate relief from stomach pain.
Patients looking for pharmaceutical prokinetics with powerful healing properties of ginger roots can consider:

- Nudge: Nudge all-natural prokinetic supplement utilizes ginger root extracts. This non-GMO and vegan capsule focuses on a complete gut health improvement with a proprietary blend composed of various natural herbs, leaves, and nuts.
- GI Motility Complex: This prokinetic combines ginger and licorice root with apple cider vinegar powder to create a supplement for managing stomach acid pH.
When Should You Take Prokinetics for SIBO
The best prokinetics for SIBO management contains a combination of natural or chemical components that promote natural gut motility. However, patients requiring small intestinal bacterial overgrowth (SIBO) management should always consult with healthcare professionals. These experts provide a dedicated treatment plan, ensuring all necessary nutrients are met.
Some common tips that medical experts recommend for patients undergoing SIBO management should take note of these general guidelines for maximizing prokinetic effectivity:

Maintain Long-Term Consistency
Managing bacteria within the gut requires long-term consistency to carefully remove overgrowth. Taking prokinetics at the recommended dosage typically requires a couple of months commitment to personal health and frequent intake since there is no quick fix for SIBO management. Follow the dosage guide set by the healthcare professional and the instructions of the prokinetic at all times.
Interact with Prescription Medicine
High growth of harmful gut bacteria can cause significant issues within the body, including the formation of ulcers and aggregation of acid reflux. Managing SIBO symptoms with antibiotic or antimicrobial supplements requires approval from a gastroenterologist to ensure that the chemical properties do not clash with the effects of prokinetics.
Prepare for Side Effects
Both natural and chemical prokinetics can cause potential risks, which makes the recovery process difficult for patients with serious gut-related illnesses. Diarrhea, bloating, abdominal pain, acid reflux, and ginger burn are common side effects associated with prolonged usage of prokinetics for treating small intestinal bacterial overgrowth.
FAQs
When improperly taken, the best prokinetics for SIBO management will host many benefits and side effects. Taking the necessary precautions and understanding the proper usage of these substances can aid patients in managing SIBO symptoms. We've compiled a list of the most common frequently asked questions first-time users might ask:
Should prokinetics be taken before or after meals?
Most options for the best prokinetics for SIBO management encourage patients to take the medication 15-30 minutes before ingesting full meals. Additional treatments or medicines can be taken alongside prokinetics to stimulate the digestive tract and help keep food down the body. This can also help with slowing the downward movement that could lead to SIBO relapse.
Are prokinetics and stimulant laxatives similar?
Both substances help de-clog bacteria from the digestive tract. However, the method used for both medications varies depending on the situation. Prokinetics stimulates the contraction of the muscle cells of the gut microbiome to promote a healthy transit while digesting. On the other hand, stimulant laxatives force contractions on both the small and large intestines to release bowels faster.
What are the common risk factors of SIBO?
Small intestinal bacterial overgrowth can cause significant digestion issues, including excess gas, bloating, diarrhea, and/or constipation. Patients diagnosed with SIBO will find it harder to ingest meals, including those rich in fiber or prebiotic nutrients, despite the fact that these foods naturally help with maintaining a healthy gut microbiome.
Key Takeaway
Some of the best prokinetics for SIBO management have proven beneficial impacts on SIBO management if properly taken alongside maintenance or preventative medications. The choice of natural ingredients allows prokinetics to be taken consistently with minimal complications.
Nudge, triphala, and artichoke are some of the best prokinetics for SIBO that help promote healthy gut motility when added into your treatment plan. Their gentler nature makes them suitable for long-term use, supporting sustained gastrointestinal health. However, those needing more dosages after conducting your SIBO tests can seek prescriptions with medical experts.
Want to start improving your gut health? Reach out to our team at contact@nudgehealth.co to get a free 30-day risk-free guarantee trial on our Nudge SIBO Formulation. At Nudge, we're committed to helping you feel better in your wellness journey!